Senna is an effective and potent purgative with its action being chiefly on the lower bowel. The anthraquinones stimulate the bowel and increase the peristaltic movements of the colon by its local action upon the intestinal wall, leading to evacuation in approximately ten hours. The herb has been recommended for people who require a soft, easily-passed stool, especially when following rectal surgery or preparing for a colonoscopy). This active purgative principle (a glycoside) was discovered in 1866.

As a vermifuge, Senna has been used to destroy and expel worms and parasites from the intestinal tract, possibly due to the herb's powerful laxative action.

By cleansing the colon, Senna may have positive results in improving skin afflictions (pimples, etc.) and helping in cases of obesity.

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